Effect of endothelial dysfunction on metabolic syndrome development

Abstract

Endothelial dysfunction in metabolic syndrome is a closely associated state and forms a vicious circle leading to metabolic and cardiovascular disorders. Inflammation activates the expression of pro-inflammatory mediators of inducible form of NO-synthesis, which leads to the synthesis of peroxynitrite in the body. In the dynamics of experimental metabolic syndrome expressed changes in endothelial dysfunction indicators are observed on the 60th day of experience.