Study of the Influence of Calcium Channel Blockers on the State of Rat Stomach Mucosa in Indomethacin-Induced Gastropathy

Abstract

Abstract The experiments were carried out on sexually mature male rats with an initial weight of 180-200 g. The preventive effect on the state of the gastric mucosa in indomethacin-induced gastropathy was studied. Two hours before reproducing the model (indomethacin 60 mg/kg, introgastrically), amlodipine and dilteazem were administered intragastrically at a dose of 20 mg/kg to animals of the first and second groups, and the third group’s animals received cinnarizine - 50 mg/kg, and the fourth group served as a control, and animal of this group received drinking water the CCB group have a distinct preventive effect on the gastric mucosa in indomethacin-induced gastropathy. Amlodipine, dilteazem, and cinnarizine clearly prevented damage of the gastric mucosa in white rats with indomethacin - induced gastropathy, in which there were a significant decrease in the total area of damage to the gastric mucosa, a decrease in the number of large and small puncture hemorrhages, as well as strip-shaped ulcers. In terms of its pharmacological activity, dilteazem was clearly superior to other drugs of the group of calcium channel blockers. It is considered possible to use calcium channel inhibitors in pathologies of the stomach and duodenum associated with arterial hypertension, coronary heart disease and arrhythmia