Debut of systemic lupus erythematosus in chronic gout arthritis (practical case)

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune systemic inflammatory disease with a variety of clinical manifestations. Gout is a systemic tophi disease characterized by the deposition of crystals of sodium monourate in various tissues and developing in connection with this inflammation in persons with hyperuricemia (HU) caused by environmental and / or genetic factors. Currently, the number of young patients is growing steadily with an increase in the number of patients with gout among women. The combination of SLE and gout is rare, and there are very few descriptions of such clinical situations. The article contains literature data concerning the combination of systemic lupus erythematosus (SLE) and gout. Peculiarities of pathogenetic mechanisms and therapeutic tactics in combination of two nosological forms are discussed. Based on the analysis of literature data, the article analyzes the features of the onset and clinical picture of SLE against the background of gout, discusses aspects of diagnosis verification, taking into account the need for early prescription of effective therapy and improvement of prognosis. The paper presents our own clinical observation of a combination of SLE and gouty arthritis in a young patient.