The Importance of Polymorphic Variants of the Β2-Adrenoreceptor Gene in the Formation of Bronchopulmonary Diseases in Children

Abstract

The association of polymorphism of rs1042714 (Gln27Glu) loci of the ADRB2 gene in children with bronchopulmonary pathology was analyzed. A molecular genetic study was conducted in children with bronchopulmonary pathology (BPP) aged 1 to 15 years of Uzbek ethnicity, which included patients with acute obstructive bronchitis (AOB), recurrent bronchial obstruction (RBO) and bronchial asthma (BA). The predictor role of the polymorphic locus rs1042714 (Gln27Glu) of the 79G allele of the A/G and G/G genotypes of the ADRB2 gene was established, which were a genetic marker of the morbidity of children with RBD and a factor in the formation of BA in children. Children with amino acid substitution C/G and genotype G/G of the Gln27Glu locus of the ADRB2 gene are at risk with severe RBO in children. The allele with the Gly16/Glu27 locus polymorphism of the ADRB2 gene in carriers of the homozygous A/A genotype provided protection against the development of BA and were associated with a milder course of RBO and BA in children.