Relationship Of Polymorphisms Of MTR Gene rs1805087, MTRR Gene rs1801394 Hohomocystein Concentration And Covid-19 Severity In Uzbek Patients

Abstract

One of the most severe complications of COVID-19 caused by SARS-CoV-2 infection is hypercoagulopathy-induced ischemic damage to vital organs, which causes many cases of disability and death in patients infected with COVID-19. Therefore, by thoroughly studying the factors that cause hypercoagulopathy, selecting patients who are prone to the development of this pathological process, and carrying out special proliferative and therapeutic procedures for them, it is possible to reduce the above-mentioned indicators of morbidity and mortality. One of the factors causing hypercoagulopathy is the polymorphisms of the MTR and MTRR genes, which are thrombophilic genes, and their study in Uzbek patients infected with COVID-19 helps to understand the correlation of different alleles of these genes with the amount of homocysteine in these studied patients, as well as their significancecan give in the pathogenesis of COVID-19.