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Title: | Genetic Aspects of Hcv Associated Arthritis: Evaluation of the Development and Clinical Course of the Disease |
Authors: | Shukurova Fazilat Narmamatovna , Karimov Marif Shakirovich , Parpibayeva Dinora Ayupovna , Eshmurzayeva Aida Abduganiyevna , Gimadutdinova Asiya Rinatovna |
Keywords: | HCV associated arthritis, Polymorphism of genes, C174G genotype of IL-6 gene |
Issue Date: | 12-Oct-2022 |
Publisher: | American Journal of Medicine and Medical Sciences |
Abstract: | To study the nature of the association of IL-6 genotypes with the development and progression of the clinical course of associated arthritis (HCVaA) with viral hepatitis C. The study examined 52 patients with HCVaA in addition to a comparison group of 23 patients with chronic hepatitis C who had no signs of arthritis. IL-6 gene polymorphism was analyzed by polymerase chain reaction. The genotype C174G of the IL-6 gene in patients diagnosed with HCVaA is dominated by the genotypes of the G-allele, homozygous G/G and heterozygous C/G. Patients with HCVaA showed a decrease in the C/C genotypic variant of the IL-6 gene in the C174G genotype and an increase in the C/G genotypic variant compared to practically healthy people. The deterioration in the development and progression of the disease in patients with HCVaA is mainly associated with an increase in the heterozygous C/G variant. To predict the development and progression of HCVaA, it is necessary to determine the C174G polymorphism of the IL-6 gene. |
URI: | http://repository.tma.uz/xmlui/handle/1/4376 |
Appears in Collections: | Thesis, Articles |
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File | Description | Size | Format | |
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Shukurova_Fazilat_American_Journal_of_Medicine_and_Medical_Sciences.pdf | Genetic Aspects of Hcv Associated Arthritis: Evaluation of the Development and Clinical Course of the Disease | 178.24 kB | Adobe PDF | View/Open |
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