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Title: | Anti-obesity activity of ethanol extract from bitter melon in mice Fed high-fat diet |
Authors: | Nal Ae Yoon, Juyeong Park, Joo Yeon Jeong, Nilufar Rashidova, Jinhyun Ryu, Gu Seob Roh |
Keywords: | Bitter melon, high-fat diet, obesity, 3T3-L1, Sirtuin 1 |
Issue Date: | Jun-2019 |
Publisher: | Korea |
Abstract: | In many cases, obesity is associated with metabolic disorders. Recently, natural compounds that may be beneficial for improving obesity have received increasing attention. Bitter melon has received attention as a diabetes treatment. NAD+-dependent deacetylase (Sirtuin 1, SIRT1) has emerged as a novel therapeutic target for metabolic diseas-es. In this study, ethanol extract of bitter melon (BME) suppressed adipocyte differentiation and significantly increased the expression of SIRT1 in fully differentiated 3T3-L1 cells. Moreover, it enhanced the activation of AMP-activated protein kinase (AMPK). In high-fat diet (HFD)-fed induced-obesity mice, BME suppressed HFD-induced increases in body weight and white adipose tissue (WAT) weight. BME also increased the expression of SIRT1 and suppressed peroxisome proliferator-activated receptor and sterol regulatory element binding protein 1 expressions of WAT from HFD-fed mice. These findings suggest that BME prevents obesity by activating the SIRT1 and AMPK pathway and that it may be a useful dietary supplement for preventing obesity. |
URI: | http://repository.tma.uz/xmlui/handle/1/544 |
ISSN: | 2465-9525 (Print) 2465-9541 (Online) |
Appears in Collections: | Thesis, Articles |
Files in This Item:
File | Description | Size | Format | |
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174.pdf | Anti-obesity activity of ethanol extract from bitter melon in mice Fed high-fat diet | 1.01 MB | Adobe PDF | View/Open |
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