Experimental substantiation of the use of hypoxia-inducible factor (HIF-1α) for the development of toxic hepatitis.

Abstract

This article provides an experimental justification for the use of hypoxia-inducible factor (HIF-1α) on the development and course of toxic hepatitis based on heliothrin intoxication. Acute heliothrin intoxication was reproduced by a single subcutaneous injection of a sublethal dose of heliothrin, prepared at the rate of 40 mg per 100 g of body weight, to rats. During the reproduction of experimental toxic hepatitis by the administration of heliothrin, it was found that the content of HIF-1 was on average equal to 0.101667±0.0022 ng/l. In blood plasma, mean HIF1 levels were 0.2136±0.0066 ng/l.