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DC Field | Value | Language |
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dc.contributor.author | Azizova, Rano | - |
dc.contributor.author | Azizova, Rano | - |
dc.date.accessioned | 2024-01-16T12:29:02Z | - |
dc.date.available | 2024-01-16T12:29:02Z | - |
dc.date.issued | 2023-12-22 | - |
dc.identifier.issn | 2770-2936 | - |
dc.identifier.issn | 2770-2936 | - |
dc.identifier.uri | http://repository.tma.uz/xmlui/handle/1/10341 | - |
dc.description.abstract | Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic focus formation and in the stimulation ofseizures. The increase of MMP- 9 activity in the epileptic focus was observed both in animal models and in clinical studies. MMP-9 contributes to formation of epileptic focus,for example, by remodeling ofsynapses. Its proteolytic action on the elements of blood-brain barrier and activation of chemotactic processes facilitates accumulation of inflammatory cells and induces seizures. Also, modification of glutamatergic transmission by MMP-9 is associated with seizures. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Texas Journal of Medical Science | en_US |
dc.subject | Matrix metalloproteinase-9, neuroinflammation, epilepsy, hippocampal sclerosis | en_US |
dc.title | Matrix metalloproteinase 9: A Representative Diagnostic Biomarker for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis | en_US |
dc.type | Article | en_US |
Appears in Collections: | Thesis, Articles |
Files in This Item:
File | Description | Size | Format | |
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Азизова РБ + 1 автор хорижий мақола декабр 1.pdf | Matrix metalloproteinase 9: A Representative Diagnostic Biomarker for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis | 232.28 kB | Adobe PDF | View/Open |
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