MOLECULAR-GENETIC BASES FOR THE DEVELOPMENT OF PATHOLOGIES OF THE PLATE OF HEMOSTASIS

Abstract

Abstract: Objective: to assess the features of the prevalence and the contribution of polymorphic variants of TNF-α genes (rs1800629) in the formation of immune thrombocytopenia (ITP) and GP IIb (T2622G) in the development of dysaggregation thrombocytopathy (DTP). Material and methods: the study included 89 patients with ITP and 71 patients with disaggregation thrombocytopathy (median age - 41 ± 1.7) for comparison of the group, 48 apparently healthy donors served as control without pathology of the hemostasis system (median age - 42 ± 1.4). Detection of TNF-α (rs1800629) and GP IIb (T2622G) gene polymorphisms was performed by SNP-PCR. Results: сarriage of heterozygous G / A genotype of rs1800629 polymorphism of TNF-α gene associated with a high risk of developing ITP, whereas the homozygous G / G genotype acts as a protective genotype in the pathogenesis of ITP. At the same time, the heterozygous T / G genotype of the T2622G polymorphism of the GPIIb gene in the main group and the hereditary dysaggregation thrombocytopathy (HDTP) subgroup are not statistically significantly associated with the development of the disease. Conclusions: the results of molecular genetic studies can be used by clinicians in screening and predicting ITP and HDTP.