ASSESSMENT OF THE DEGREE OF ASSOCIATION OF IL-17A GENE POLYMORPHISMS (rs2275913), IL-17F (rs763780) AND IL-23R (11209026) WITH THE SEVERITY OF CLINICAL AND INSTRUMENTAL MANIFESTATIONS OF RHEUMATOID ARTHRITIS

Abstract

The influence of the association of polymorphic genes IL17A (rs2275913), IL- 17F (rs763780) and IL23R (11209026) on the clinical manifestations of RA in Uzbekistan was studied. The IL23R gene receptor polymorphism (11209026) was assessed by analyzing DNA samples using standard PCR. An association was found between carriage of unfavorable genotypes of the IL17A gene (rs2275913) and the duration of RA. There is a tendency to increase the duration of the articular form of the disease to 15 years or more in carriers of genotypes G/A + A/A of the IL17A polymorphic gene (rs2275913) by almost three times (χ2=3.61; P=0.057; OR=2.57; 95% CI: 0.96-6.86), which allows us to consider them as prognostic markers for the long-term course of RA. Unfavorable genotypes of the IL17A (rs2275913) and IL-17F (rs763780) genes as predictors of the development of severe FNS in patients with articular RA. There is a pronounced tendency towards an increase in unfavorable genotypes G/A + A/A of the IL17A polymorphic gene (rs2275913) by more than 5 times (χ2=2.28; P=0.13; OR= 5.08; 95% CI:0.50-51.38) and A/G +G/G polymorphism of the IL-17F gene (rs763780) almost 5 times (χ2=2.66; P=0.10; OR=4.83; 95% CI:0.62-37.77) among patients with FNS 3 with articular form of RA. Associations between the degree of RA activity and polymorphic genes IL17A (rs2275913), IL-17F (rs763780) and IL23R (11209026) with articular (χ2<3.84; P>0.05) and articular-visceral forms of the disease (χ2<3.84; P>0.05) not found