The role of angiotensin-converting enzyme of i/d gene polymorphism in the diagnosis of chronic heart failure with anemia of various etiologies

Abstract

This paper examines the rate of occurrence of the I/D polymorphism of the enzyme gene that converts angiotensin in patients with anaemia of various etiologies of chronic heart failure and the importance of polymorphism in the development of the disease. The allele and genotypes of the angiotensin-converting enzyme polymorphism allele and genotypes were compared with the prevalence of chronic heart failure in iron deficiency anaemia, chronic disease, and renal anaemia, while the D allele and DD genotype in the renal anaemia group were iron deficiency anaemia, respectively (64.1 vs 49), 1% (r = 0.05) and (47.1 vs 36) 11.1% (r = 0.3), chronic disease anaemia compared to the group (62.5 vs 49) 13.5%, (r <0.05) and (45.5 vs 36) were 9.5% (r = 0.35) lower I allele and genotype II in the renal anaemia group corresponded to 15% in the group of iron deficiency anaemia (51 vs 36) and 20.2% (r <0.05) (r <0.05) in the group of chronic diseases, respectively. (37.5 vs 51) 13.5% and (25 vs. 39) 14% (r <0.05). Patients with CHF carrying the genotype II of the angiotensin-converting enzyme gene I/ D polymorphism have a significantly higher probability of developing renal anaemia, and the D allele of this polymorphism has a protective effect against the development of renal anaemia.