Changes In Biochemical Indexes Of Rats’ Blood During Chronic Ethanol Poisoning And Treatment Them With Herbal Preparations

Abstract

Alcoholism worldwide is one of the main causes of premature death of the population. Alcohol is a leading etiological factor in liver damage, this necessitates the search for new, more effective pharmacological drugs with a pathogenetic orientation with antioxidant and metabolic effects. Promising are Geranium saxatile and proanthocyanidins active ingredients ah. Purpose: to experimentally substantiate the feasibility of using geranil for the protection of organs and tissues in chronic alcohol intoxication. Material and methods: Chronic alcohol intoxication in 50 rats was modeled by intragastric administration of 25% ethanol at a dose of 10 ml / kg for 28 days daily. Experimental pharmacotherapy with geranil (main group) and carsil (comparison drug) was carried out from 21 days of the experiment for 7 days at a dose of 100 mg / kg. The determination of serum biochemical parameters was carried out on a MINDRAYBA-88A biochemistry analyzer (China) using commercial reagent firms from CYPRESS Diagnostics (Belgium). Digital material processed by the method of variation statistics. Results: The results of the study showed the development of structural and functional disorders of hepatocytes under the influence of ethanol and its metabolic products, leading to a change in blood biochemical parameters and liver indicators. Experimental pharmacotherapy with carsil, to a greater extent geranyl, reduced hyperenzymes, hyperbilirubinemia, hypercholesterolemia, and the pharmaco-metabolizing function of hepatocytes, due to a decrease in hyperlipoperoxidation. Conclusion: Experimental pharmacotherapy with a new drug from the group of proanthacyanidins geranyl and bioflavonoids - Carsil leads to a decrease in lipid peroxidation intensity, causing restoration of the structural and functional parameters of hepatocytes. Geranil turned out to be more effective in this regard.