Evaluation of the Pharmacological and Therapeutic Effects of Drugs of Natural Origin in the Management of Biliary Insufficiency in Tetracycline Induced Hepatitis

Abstract

The effectiveness of the medicine- Convaren for restoration of bile-forming function of liver was studied in comparison with Celagrip, Lesbokhol, Liv.52, and Silibor on tetracycline induced acute hepatitis model. Experimental studies were conducted on white male rats with an initial body weight of 170-200 g. The drug lesion was reproduced by daily oral administration of tetracycline at a dose of 500 mg/kg into the stomach using a metal probe for 5 days. The animals were treated with Celagrip (25 mg/kg), Lesbokhol (25 mg/kg), Convaren (50 mg/kg), Liv.52 (100 mg/kg), and Silibor (80 mg/kg) for 6 days. Under the influence of Convaren, the excretion of bile increased by 48,2%, bile acids excretion increased by 89,6%, cholesterol by 94,8%, and bilirubin by 32,6% in tetracycline-induced hepatitis. Convaren showed a more significant impact on the improvement of the bile-secretion activity of the liver in drug-induced hepatitis compared with Silibor, Liv.52, Celagrip and Lesbokhol.