Epigenetic and genetic determinants of endometrial hyperplastic processes in perimenopausal obese women

Abstract

Endometrial hyperplasia (EH) in perimenopause is almost always accompanied by abnormal uterine bleeding (AUB), the nature of which is due to hormonal, biochemical, molecular genetics, and local violation of the regulation of cell proliferation. The aim of the study was to search for genetic markers to increase the effectiveness of therapy in the future and reduce the frequency of relapses of EH in perimenopausal women, taking into account the metabolic profile, and the potential presence of chronic inflammation, recurrent AUB. 225 perimenopausal women were examined. The main group of women with AUB was divided into 2 subgroups: obese (n=71) and non-obese (n=49). The control group consisted of 105 healthy women. Histological examination of endometrial biopsies was performed, as well as genotyping of polymorphisms of 4 genes by PCR: s1800629I TNF-α, Arg72Pro of the TP53 gene, ER, and PR gene. The determination of a stable relationship between the identified polymorphisms of both receptor and apoptotic and proapoptotic genes in women with EH and obesity indicates the feasibility of conducting genetic studies to predict the risk of progression and recurrence of EH in peri - and postmenopausal women