Certain indicators of diclofenac sodium pharmacokinetics in patients with rheumatoid arthritis considering comorbid states

Abstract

Much attention is paid to pharmacokinetic (FK) researches for studying the processes of supply, distribution, biotransformation and excretion of medications at the present time, as well as identifying links between medical substances concentration and (or) its metabolites in biological fluids and tissues, and its pharmacological effect. In the treatment of rheumatoid arthritis (RA), non-steroidal anti-inflammatory drugs (NSAID) are widely used for a symptom therapy, where Diclofenac Sodium (DS) is most commonly prescribed. Duration of anti-inflammatory effect, effectiveness of NSAID in whole are directly dependent on the level of effective concentration of medications and circulation duration in blood in free form.