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Title: | Study the antifibrous efficacy of plant proanthocyanidin in rats with chronic heliotrine liver damage |
Authors: | A.N. Aripov, O.A. Aripov, L.L. Akhundjanova,A.U. Nabiev, D.A. Nabieva,T.T. Khamroev |
Keywords: | Heliothrin, fibrosis and cirrhosis of the liver, hepatoprotective, antifibrotic, proanthocyanidins, toxic hepatitis, yantacin. |
Issue Date: | 18-May-2022 |
Abstract: | Under experimental conditions, the effect of plant proanthocyanidin – yantacin isolated from a camel thorn plant (Alhagi pseudalhagi) – Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis was studied. The studies were conducted on male rats with a body weight of 100 ±10 g. The effect of yantacin on the general and biochemical parameters of the blood, as well as the amount of NO – nitrates (in connection with lipoproteins), proteins in the blood against the background of heliotrine liver damage was studied. At the same time, yantacin demonstrated a significant protective effect compared to the control group on the detected fibrosis, according to which certain indicators, against the background of chronic toxic liver damage. In this regard, a more extensive in-depth study of the effect of the studied substance plant proanthocyanidin on normal and impaired liver activity is carried out. |
URI: | http://repository.tma.uz/xmlui/handle/1/3180 |
ISSN: | 2752-6712 |
Appears in Collections: | Thesis, Articles |
Files in This Item:
File | Description | Size | Format | |
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Набиева Д.А. 2.pdf | 963.96 kB | Adobe PDF | View/Open |
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