Microrna-122: A Prognostic Marker of the Pathological State of the Liver

Abstract

This article provides information on the role of miRNAs in the progression of chronic diffuse diffuse liver diseases from the stage of chronic viral hepatitis to severe fibrosis. The study of new parameters for predicting the nature of the course, the rate of progression of liver fibrosis, the risk of developing HCC is of particular importance. In this direction, great prospects are opening up in the field of genomics. Among the total array of works, a significant share is occupied by studies of single nucleotide polymorphisms, freely circulating DNA, endosomal RNA and their significance in the pathogenesis of various diseases. The discovery in 2002 of microRNA-122 (miR 122) was an event in hepatology due to the functional features of this RNA cluster