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DC Field | Value | Language |
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dc.contributor.author | Evgeniya Shalaevа, Ulugbek Kasimov, Markus Laimer, Hugo Saner | - |
dc.date.accessioned | 2022-11-30T02:55:05Z | - |
dc.date.available | 2022-11-30T02:55:05Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.uri | http://repository.tma.uz/xmlui/handle/1/4703 | - |
dc.description.abstract | Abstract The aim of the study was to examine the predictive value of coronary computed tomographic angiography (CCTA) and coronary artery calcium score (CACS) on 1-year all-cause mortality in type 2 diabetes (T2D) patients with peripheral artery disease (PAD) undergoing partial foot amputations (PFA). Methods: This is a single-center prospective cohort study including 199 consecutive patients with T2D, PAD (mean age 62.3 ± 7.2 years; 62.8% males), and preoperative CACS and CCTA undergoing PFA and followed-up over 1 year. Results: Over a period of 1 year follow-up, a total of 35 (17.6%) participants died. The area under ROC curve to predict mortality for the CACS was 0.835 (95% CI:0.769–0.900), for CCTA 0.858 (95% CI:0.788–0.927). After adjustment for confounders, compared to no-stenosis on CCTA (reference), the risk of all-cause mortality in non-obstructive coronary atery disease (CAD) increased (HR = 1.38, 95% CI [0.75–12.86], p = .284), 1-vessel obstructive CAD (HR = 8.13, 95% CI [0.87–75.88], p = .066), 2-vessels (HR = 10.94, 95% CI [1.03–115.8], p = .047), and 3-vessels (HR = 45.73, 95% CI [4.6– 454.7], p = .001) respectively. Increasing levels of CACS tended to be associated with increased risk of all-cause mortality (HR = 1.002, 95% CI [1.0–1.003], p = .061). 61/95 patients with obstructive CAD underwent coronary revascularization. Conclusions: Coronary artery calcium score and CCTA have a high predictive value for 1-year all-cause mortality in T2D patients undergoing minor amputations and may be considered for preoperative risk assessment allowing timely preventive interventions. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Европа | en_US |
dc.subject | Coronary artery disease, coronary computed tomographic angiography, coronary artery calcium score, type 2 diabetes, peripheral artery disease, partial foot amputation | en_US |
dc.title | Coronary artery calcium score and coronary computed tomography angiography predict one-year mortality in patients with type 2 diabetes and peripheral artery disease undergoing partial foot amputation | en_US |
dc.type | Article | en_US |
Appears in Collections: | Thesis, Articles |
Files in This Item:
File | Description | Size | Format | |
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Scopus Kasimov.pdf | 1.16 MB | Adobe PDF | View/Open |
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