New aspects of pathogenesis, screening and prevention of preeclampsia

Abstract

Complications of preeclampsia (PE) - the cause of 30% of maternal deaths and severe morbidity. To date, the pathogenesis of this terrible complication of gestation has not been fully studied, prevention issues are debated. The latest foreign studies from the PubMed, Medline and ISI Web of Knowledge databases on this issue summarize several aspects of PE pathogenesis: endoplasmic reticulum stress, apoptosis, endothelial cell activation, inflammatory response, microthrombosis and thrombotic microangiopathy (TMA), allogeneic incompatibility. Strategies for determining individual risk, screening and preventing PE are also considered.