РЕГУЛЯЦИЯ АТФ-ЗАВИСИМОГО К+ КАНАЛ МИТОХОНДРИЙ ПЕЧЕНИ ПРИ ДЕЙСТВИЯ ПОЛИФЕНОЛОВ

Abstract

Objective: To study the effect of polyphenols rutan, getazan and euphorbin on the mitotic K+ATP channel of rat liver. Materials and methods: Conductivity of ATP-dependent K+ channels (0.3-0.4 mg/ml) in rat liver mitochondria was determined by changes in optical density at a wavelength of 540 nm in 3-ml cells. Results: The influence of the polyphenols rutan, getazan and euphorbin on the mitotic K+ATP channel in rats was studied. The results showed that the polyphenols rutan, getasan, and euphorbin activated mitochondrial channels in rats. Conclusion: The polyphenols of rutan, getasan and euphorbin have the ability to activate the mito K+ATP channel, which means that in the future they can be used to develop new drugs for cardioprotection and hypoxia.