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http://repository.tma.uz/xmlui/handle/1/6140
Title: | Experimental substantiation of the use of hypoxia-inducible factor (HIF-1α) for the development of toxic hepatitis. |
Authors: | Kurbonova Z.Ch., Sayfutdinova Z.A., Muhammadiev X.G., Xashimova G.T |
Keywords: | hypoxia-inducible factor; heliotrin intoxication; experimental toxic hepatitis; aryl hydrocarbon receptor transolator. |
Issue Date: | Oct-2022 |
Publisher: | Инновационное развитие науки и образования 2022 |
Series/Report no.: | doi.org/10.5281/zenodo.7353873; |
Abstract: | This article provides an experimental justification for the use of hypoxia-inducible factor (HIF-1α) on the development and course of toxic hepatitis based on heliothrin intoxication. Acute heliothrin intoxication was reproduced by a single subcutaneous injection of a sublethal dose of heliothrin, prepared at the rate of 40 mg per 100 g of body weight, to rats. During the reproduction of experimental toxic hepatitis by the administration of heliothrin, it was found that the content of HIF-1 was on average equal to 0.101667±0.0022 ng/l. In blood plasma, mean HIF1 levels were 0.2136±0.0066 ng/l. |
URI: | http://repository.tma.uz/xmlui/handle/1/6140 |
Appears in Collections: | Thesis, Articles |
Files in This Item:
File | Description | Size | Format | |
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Kurbonova.pdf | 842.54 kB | Adobe PDF | View/Open |
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