ASSESSMENT OF INDICATORS OF TOXIC DAMAGE OF HEPATOCITES IN CHRONIC LIVER DISEASES

Abstract

Objective: to study enzymes of different localization of hepatocytes in endogenous intoxication in patients with chronic liver diseases. Material and methods: in patients with chronic liver diseases, the activity of hepatocyte enzymes, as well as marker enzymes of mitochondria, was determined. Results: in patients with chronic diffuse liver diseases, against the background of the formation of reactive oxygen species and endogenous intoxication, hyperenzymemia was noted due to a violation of the membrane structures of hepatocyte mitochondria, as well as stimulation of macrophages in the liver, which was expressed in an increase in the concentration of cystatin C and cathepsin B in the blood. An increase in the activity of the lysosomal enzyme cathepsin B may be one of the reasons for the death of hepatocytes and the acceleration of apoptosis. Conclusions: in patients with chronic liver disease, against the background of endogenous intoxication and an increase in lipid peroxidation products, cytolytic damage to hepatocytes and hyperfermentemia occur.