Experimental Toxic Myocarditis When Exposed to Pesticides

Abstract

Background. Very often one of the etiological causes of heart disease is the toxic factor. Currently, different chemical products are used in agriculture for the treatment of grape, vegetable and especially cotton fields. Most chemical compounds such as pesticides have adverse effects on the body. At the present time, more than 1000 kinds of pesticides are being used worldwide and every еar their number is increasing. Methods. Research has scientifically substantiated the results of inspections conducted on 205 white laboratory rats during early postnatal ontogenesis. In the complex morphological studies, which include in its membership general histologic, histochemical techniques organometal, morphometry, scanning electron microscopy, transmission electron microscopy, ECG heart and mathematical modelling and forecasting toxic myocarditis it was used. Conclusion. The maximum increase in length, width and anteroposterior heart size observed from birth to 6th day and changes its location craniocaudal direction. From the moment of birth until 21 days of age, the ratio of the relative weight of the heart to the body weight is reduced from 1.75% to 1.1%. The toxic effects of pesticides on the heart of rats demonstrated specific pathological morphological changes, that is, there was disorganization of fibrous structures in the wall of arterioles and capillaries, proliferation owns connective cells and protein dystrophy muscle fibers of the myocardium, and loosening discomplexation of myofibrils violation of the nuclear-cytoplasmic ratio.