ANALYSIS OF ANTIMICROBIAL AND ANTIFUNGAL ACTIVITY OF SYNTHETIC STRUCTURAL COMPOUNDS

Abstract

This analysis examines data from authoritative sources, as well as some data without changes and citations. A review of 1,3,4-oxadiazole derivatives shows a high potential for their antimicrobial activity. The new structures have a very wide range of activity, from bacteria and fungi to protozoa and viruses. The possible mechanisms of action of some of the new compounds, which are based on the inhibition of various enzymes, for example, DNA gyrase, enoyl reductase and lanosterol-14α-demethylase, are described. Many of the new derivatives exceed the activity of already known antimicrobials. The variety of new structures and their high activity confirm their value as new drugs in the fight against antimicrobial resistance. Further studies are needed to confirm their efficacy and safety in vivo. The development of antimicrobial resistance around the world is forcing scientists to look for new compounds to which microbes would be sensitive. Many new structures contain a 1,3,4- oxadiazole ring, which exhibit various antimicrobial activity, for example, antibacterial, antituberculous, antifungal, antiprotozoal and antiviral. In many publications, the activity of new compounds exceeds the activity of already known antibiotics and other antimicrobials, so their potential as new drugs is very promising. The review of active antimicrobial derivatives of 1,3,4-oxadiazole is based on the literature for the period last 5 - 6 years.Thus, several conclusions can be drawn regarding the relationship between structure and activity. In the amino derivatives of 1,3,4-oxadiazole, it can be seen that the additional presence of another heterocyclic ring can expand the spectrum of antimicrobial activity.