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http://repository.tma.uz/xmlui/handle/1/8066| Title: | Hif-1 regulates the transition to anaerobic metabolism |
| Authors: | Xashimova G.T., Muhammadiev X.G, Valijonova M, Xidoyatova M. |
| Keywords: | hypoxia; ischemia; hypoxia-inducible factor; homeostasis; anaerobic glycolysis; Krebs cycle. |
| Issue Date: | Apr-2023 |
| Publisher: | KLINIK LABORATOR DIAGNOSTIKADA INNOVATSION TEXNOLOGIYALARDAN FOYDALANISH, MUAMMOLAR VA YECHIMLAR |
| Series/Report no.: | №2; |
| Abstract: | HIF-1 is one of the main genes coordinating this shift by inducing various glycolytic enzymes and glucose transporters such as aldolase A and pyruvate kinase M, which help cells efficiently generate energy in a hypoxic environment. In addition to increasing the expression of these enzymes, HIF-1 reduces mitochondrial oxygen consumption by activating pyruvate dehydrogenase kinase I and stopping the citric acid cycle. |
| URI: | http://repository.tma.uz/xmlui/handle/1/8066 |
| Appears in Collections: | Thesis, Articles |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Hif-1 regulates the transition to anaerobic metabolism.pdf | 1.36 MB | Adobe PDF | View/Open |
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