ОЦЕНКА МАРКЕРОВ ПОВРЕЖДЕНИЯ КЛУБОЧКОВ ПРИ МЕТАБОЛИЧЕСКОМ СИНДРОМЕ У ЖЕНЩИН В ПОСТМЕНОПАУЗАЛЬНОМ ПЕРИОДЕ

Abstract

To evaluate the significance of laboratory biomarkers of kidney damage in metabolic syndrome in post menopausal women. Material and methods: 82 (82%) women with kidney damage in the metabolic syndrome in the postmenopausal period were under observation. The age of the patients was from 40 to 65 years (54.0±4.8). The control group included 18 healthy female volunteers of comparable age. The study was carried out in a multidisci plinary TMA clinic together with endocrinologists, obstetricians-gynecologists and nephrologists. Results: In women with metabolic syndrome in the postmenopausal period, there was an increase in the content of malondialdehyde in the blood, microalbuminuria, an increase in the level of cystatin C and β2-microglobulin, which is a reliable sign of glomerular filtration disorders. Determination of markers of damage to the proximal tubules of the kidneys in women with metabolic syndrome in the postmenopausal period has a diagnostic value for assessing disorders in the tubu lointerstitial system of the kidneys. Conclusions: The determination of these markers will make it possible to identify violations of the functional state of the kidneys as early as possible and to identify groups of patients who are especially in need of effective therapy