Abstract:
Systemic sclerosis, or systemic scleroderma (SSD), is an autoimmune disease of connective
tissue, the main clinical signs of which are caused by widespread microcirculation disorders,
fibrosis of the skin and internal organs. According to morphological studies, 80% of patients with
SSD have kidney changes, including those not associated with rheumatic diseases. While the
prevalence of sclerodermic renal crisis is currently estimated at 2-5%, an asymptomatic decrease in
renal function ("mute uremia") due to the presence of multimorbid and comorbid pathology is
much more often noted. Its frequency in patients with SSD can reach 55%.
