The clinical significance of anti-fibrillarin (u3-rnp) antibodies in systemic sclerosis

Abstract

Systemic sclerosis is a chronic autoimmune connective tissue disease, characterized by endothelial dysfunction, immune abnormalities and progressive fibrosis of skin and multiple inner organs. The main marker of an abnormal immune response is circulating autoantibodies, which are found in more than 95% of patients with systemic sclerosis. It is important to study the clinical, immunological, diagnostic and prognostic significance of autoantibodies, especially anti-fibrillarin antibodies produced against the fibrillarin protein.