"Post-traumatic immunosuppression and the possibility of their correction"

Abstract

Serum concentrations of soluble activation receptors (sCD25 and sCD 95), cytokines (IL-2, IL-6,and TNF-α) were studiedin the dynamics of traumatic disease treatment. Those submitted data points out the development of posttraumatic immunosuppression in the early stages of observation, such as neutrophilic leukocytosis, relative lymphopenia, increase of sCD25 and sCD95, cytokines IL-6 and TNF-α, reduction of IL-2, which are more pronounced in patients at risk of posttraumatic complications development. Basic therapy corrects only some parameters of immunity, but the usage of polyoxidonium entirely recover affected immunological indicators. It is recommended to include polyoxidonium into basic therapy in patients with traumatic disease at early stages.