Abstract:
Serum concentrations of soluble activation receptors (sCD25 and sCD
95), cytokines (IL-2, IL-6,and TNF-α) were studiedin the dynamics of traumatic
disease treatment. Those submitted data points out the development of posttraumatic
immunosuppression in the early stages of observation, such as neutrophilic
leukocytosis, relative lymphopenia, increase of sCD25 and sCD95, cytokines IL-6 and
TNF-α, reduction of IL-2, which are more pronounced in patients at risk of
posttraumatic complications development. Basic therapy corrects only some
parameters of immunity, but the usage of polyoxidonium entirely recover affected
immunological indicators. It is recommended to include polyoxidonium into basic
therapy in patients with traumatic disease at early stages.
