Age-related, metabolic, and post-traumatic osteoarthritis phenotypes in II and III stage of knee joints osteoarthritis

Abstract

Osteoarthritis (OA) is the most prevalent arthritis in rheumatology. Chondrocytes are changed degeneratively, and OA occurs joint destruction process. As a result, patients suffer from pain, and limited movement, disability. OA has heterogeneity. Improving a new model of understanding OA based on a phenotype-guided approach is needed. Studying OA phenotypes improve the chance of individual predicting of disease and aimed to define OA modifying drugs.