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Title: | Matrix metalloproteinase 9: A Representative Diagnostic Biomarker for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis |
Authors: | Azizova, Rano Azizova, Rano |
Keywords: | Matrix metalloproteinase-9, neuroinflammation, epilepsy, hippocampal sclerosis |
Issue Date: | 22-Dec-2023 |
Publisher: | Texas Journal of Medical Science |
Abstract: | Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic focus formation and in the stimulation ofseizures. The increase of MMP- 9 activity in the epileptic focus was observed both in animal models and in clinical studies. MMP-9 contributes to formation of epileptic focus,for example, by remodeling ofsynapses. Its proteolytic action on the elements of blood-brain barrier and activation of chemotactic processes facilitates accumulation of inflammatory cells and induces seizures. Also, modification of glutamatergic transmission by MMP-9 is associated with seizures. |
URI: | http://repository.tma.uz/xmlui/handle/1/10341 |
ISSN: | 2770-2936 2770-2936 |
Appears in Collections: | Thesis, Articles |
Files in This Item:
File | Description | Size | Format | |
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Азизова РБ + 1 автор хорижий мақола декабр 1.pdf | Matrix metalloproteinase 9: A Representative Diagnostic Biomarker for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis | 232.28 kB | Adobe PDF | View/Open |
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