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Title: | СРАВНИТЕЛЬНОЕ ИССЛЕДОВАНИЕ ВЛИЯНИЯ СИЛИБОРА И ДИПСАКОЗИДА НА ФАРМАКОКИНЕТИКУ АНТИПИРИНА ПРИ ОСТРОМ ЭКСПЕРИМЕНТАЛЬНОМ ГЕПАТИТЕ |
Authors: | Джанаев, Г.Ю. |
Keywords: | Ключевые слова: монооксигеназная система гепатоцитов, токсический гепатит, дипсакозид, силибор. Keywords: monooxygenase system of hepatocytes, toxic hepatitis, dipsacoside, silibor. |
Issue Date: | 2020 |
Publisher: | Sciences of Europe |
Series/Report no.: | # 48, (2020); |
Abstract: | In an experiment in mature animals with acute toxic hepatitis, the pharmacokinetic parIn an experiment in mature animals with acute toxic hepatitis, the pharmacokinetic parameters of antipyrine as a test drug for evaluating the monooxygenase enzyme system (MOS) of hepatocytes were studied. It was found that in acute toxic hepatitis induced by Tetrachloromethane, there is a marked violation of the pharmacokinetics of antipyrine, indicating a decrease in the functional activity of MOS. Experimental therapy with dipsacoside to a greater extent than silibor eliminates the violation of the latter. It is believed that the restoration of the functional activity of MOS of hepatocytes is one of the hepatoprotective effects of dipsacoside.ameters of antipyrine as a test drug for evaluating the monooxygenase enzyme system (MOS) of hepatocytes were studied. It was found that in acute toxic hepatitis induced by Tetrachloromethane, there is a marked violation of the pharmacokinetics of antipyrine, indicating a decrease in the functional activity of MOS. Experimental therapy with dipsacoside to a greater extent than silibor eliminates the violation of the latter. It is believed that the restoration of the functional activity of MOS of hepatocytes is one of the hepatoprotective effects of dipsacoside. |
URI: | http://repository.tma.uz/xmlui/handle/1/1650 |
ISSN: | 3162-2364 |
Appears in Collections: | Thesis, Articles |
Files in This Item:
File | Description | Size | Format | |
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4. Хориж Глицерам_Science_of_Europe,_Чехия_2020.pdf | 363.09 kB | Adobe PDF | View/Open |
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