Abstract:
In an experiment in mature animals with acute toxic hepatitis, the pharmacokinetic parIn an experiment in mature animals with acute toxic hepatitis, the pharmacokinetic parameters of antipyrine
as a test drug for evaluating the monooxygenase enzyme system (MOS) of hepatocytes were studied. It was found
that in acute toxic hepatitis induced by Tetrachloromethane, there is a marked violation of the pharmacokinetics
of antipyrine, indicating a decrease in the functional activity of MOS. Experimental therapy with dipsacoside to a
greater extent than silibor eliminates the violation of the latter. It is believed that the restoration of the functional
activity of MOS of hepatocytes is one of the hepatoprotective effects of dipsacoside.ameters of antipyrine
as a test drug for evaluating the monooxygenase enzyme system (MOS) of hepatocytes were studied. It was found
that in acute toxic hepatitis induced by Tetrachloromethane, there is a marked violation of the pharmacokinetics
of antipyrine, indicating a decrease in the functional activity of MOS. Experimental therapy with dipsacoside to a
greater extent than silibor eliminates the violation of the latter. It is believed that the restoration of the functional
activity of MOS of hepatocytes is one of the hepatoprotective effects of dipsacoside.
