СРАВНИТЕЛЬНОЕ ИССЛЕДОВАНИЕ ВЛИЯНИЯ СИЛИБОРА И ДИПСАКОЗИДА НА ФАРМАКОКИНЕТИКУ АНТИПИРИНА ПРИ ОСТРОМ ЭКСПЕРИМЕНТАЛЬНОМ ГЕПАТИТЕ

Abstract

In an experiment in mature animals with acute toxic hepatitis, the pharmacokinetic parIn an experiment in mature animals with acute toxic hepatitis, the pharmacokinetic parameters of antipyrine as a test drug for evaluating the monooxygenase enzyme system (MOS) of hepatocytes were studied. It was found that in acute toxic hepatitis induced by Tetrachloromethane, there is a marked violation of the pharmacokinetics of antipyrine, indicating a decrease in the functional activity of MOS. Experimental therapy with dipsacoside to a greater extent than silibor eliminates the violation of the latter. It is believed that the restoration of the functional activity of MOS of hepatocytes is one of the hepatoprotective effects of dipsacoside.ameters of antipyrine as a test drug for evaluating the monooxygenase enzyme system (MOS) of hepatocytes were studied. It was found that in acute toxic hepatitis induced by Tetrachloromethane, there is a marked violation of the pharmacokinetics of antipyrine, indicating a decrease in the functional activity of MOS. Experimental therapy with dipsacoside to a greater extent than silibor eliminates the violation of the latter. It is believed that the restoration of the functional activity of MOS of hepatocytes is one of the hepatoprotective effects of dipsacoside.