Please use this identifier to cite or link to this item:
http://repository.tma.uz/xmlui/handle/1/8755
Title: | Прогнозирование дисфункции эндотелия у больных псориатическим артритом |
Authors: | Мирахмедова Хилола Тухтасиновна, Абдуллаев Улугбек Сайфуллаевич |
Keywords: | psoriatic arthritis, interleukin 17, endo-thelin-1, immunological disorders |
Issue Date: | May-2023 |
Publisher: | Toshkent tibbiyot akademiyasi axborotnomas |
Abstract: | There is evidence of an increased risk of atherosclerosis and cardiovascular disease (CVD) in in-flammatory rheumatic diseases. Psoriatic arthritis (PsA) is a seronegative spondyloarthropathy (SpA). Inflamma-tion in arthritis, as well as traditional risk factors for ath-erosclerosis, together with cytokines and adhesion mole-cules, influence the activation and dysfunction of the en-dothelium. Interleukin 17 (IL-17) and endothelin-1 (ET-1) activate and deregulate endothelial function and may increase the risk of atherosclerosis. Serum IL-17 and ET-1 are believed to be associated with the inflammatory process in PsA. In addition, IL-17 stimulates the produc-tion of fibrinogen by the liver and is also involved in the activation of endothelial dysfunction. |
URI: | http://repository.tma.uz/xmlui/handle/1/8755 |
ISSN: | 2181-7812 |
Appears in Collections: | Thesis, Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
21_статья_Мирахмедова, Абдуллаев_У_С_Вестник_ТМА_№5_2023.pdf | 909.67 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.