Non-Tuberculosis Mycobacteria In Phthisio- Pulmonological Practice In The Republic Of Uzbekistan

Abstract

Background: With the widespread increase in the incidence of mycobacteriosis, a thorough study of this disease is required in order to develop algorithms for diagnosis, treatment and monitoring. It has been shown that patients with local immunodeficiency - chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis, pneumoconiosis and other respiratory diseases Methods: The study involved 14544 patients who had applied to the Republican Specialized Scientific and Practical Medical Center of Phthisiatry and Pulmonology under the Ministry of the Health of Uzbekistan. The ATS / IDSA diagnostic algorithm was used as the criteria for non-tuberculosis mycobacteria detection. Sputum, bronchoalveolar lavage fluid, feces, pleural fluid, surgical material, punctate, urine were taken for biological analysis. Results: Out of 14544 patients, non-tuberculosis mycobacteria were detected in 38 (0.26%) patients; while Mycobacterium avium complex - in 17 (44.7%), among men - in 26 (68.4%), among women - in 12 (31.6%). Non- tuberculosis mycobacteria were predominantly excreted in sputum - in 27 (71.2%) patients, less often in urine - in 6 (15.7%) and from bronchoalveolar fluid - in 2 (5.3%), in isolated cases in pleural fluid, gastroduodenal lavage and from the operating material. Conclusion: According to the results of a retrospective study of the treatment results of 14544 patients who underwent inpatient therapy for the period from 2009 to 2019. with suspected respiratory TB, it was revealed that NTMB are detected annually in biological samples of 4.0 patients.