Cartilage oligomeric matrix protein (comp) in early diagnosis of osteoarthritis

Abstract

Sixty patients with radiologically determined 0-II stages of knee joint osteoarthritis aged 50.3±4.4 years old with average duration 5.4±3.6 years were enrolled in the study. At the same time ten healthy individuals (average age 47.5±7.1years old) of the age and gender compatible with the patients of OA group were also enrolled in the study. According to the results of the study radiological stage of osteoarthritis, progression and duration are characterized by certain structural changes. Within preradiological stage rise of cartilage oligomeric matrix protein (COMP) in blood serum indicates early destruction of cartilage.