Distribution of Allel Variants and Genotypes of Il4, Il10, Il12b, Tlr2 Genes in the Group of Patients with CPRS

Khasanov U.S.   Djuraev J.A     Vokhidov U. N.          Botirov A.J.  Akhundjanov N.A.  Ergashev U.M.  Khodjanov Sh.K. Shaumarov A.Z

dc.contributor.author	Khasanov U.S. Djuraev J.A Vokhidov U. N. Botirov A.J. Akhundjanov N.A. Ergashev U.M. Khodjanov Sh.K. Shaumarov A.Z
dc.date.accessioned	2022-01-02T12:29:49Z
dc.date.available	2022-01-02T12:29:49Z
dc.date.issued	2021-01-05
dc.identifier.issn	1583-6258
dc.identifier.uri	http://repository.tma.uz/xmlui/handle/1/1387
dc.description	Tashkent Medical Academy Otorhynolaringology department	en_US
dc.description.abstract	Due to the prevalence of polyposis rhinosinusitis (PRS) and its tendency to recurrence, the search for new pathogenetic mechanisms is still relevant. Despite the many classifications and attempts at endotyping this disease, the question remains open. The modern direction of personalized medicine is the study of immunological mechanisms and the search for genetic predictors. One of these targets is interleukin (IL) 10, which is considered a new key factor in the development of allergic diseases, including bronchial asthma, allergic rhinitis and ORS. Interest was aroused not only by this cytokine and its ST2 receptor, but also by single nucleotide polymorphisms of the IL-10 gene, which may determine the severity of the course of the disease	en_US
dc.language.iso	en_US	en_US
dc.subject	Chronic Polyposis Rhinosinusitis, IL, Nasal Cavity, Eosinophil, Gene Polymorphism, Polyp.	en_US
dc.title	Distribution of Allel Variants and Genotypes of Il4, Il10, Il12b, Tlr2 Genes in the Group of Patients with CPRS	en_US
dc.type	Article	en_US