Studying the Т-786С Polymorphism NO Synthase Gene of Chronic Heart Failure with Kidney Dysfunction

Abstract

The aim of our study was to evaluate the role of NO synthase and T786C polymorphism of the NO synthase gene in patients with chronic heart failure (CHF). In patients with CHF 114 Uzbeks have been studied the alleles and genotypes T786C polymorphism of the NO synthase gene. The progression of kidney dysfunction in patients with CHF was accompanied by a decrease in the expression of NO synthase, as evidenced by a decrease in the activity of endothelial NO synthase, NO metabolites (NO2-NO3), highly significant in the group of patients with eGFR <60 ml / min. On the basis of genetic models in Uzbek patients with CHF, the contribution of the T / C genotype T786C polymorphism of the NO-synthase gene increases the risk of disease progression in the group of patients with an eGFR <60 ml / min and makes it possible to determine this genotype as an in-dependent marker of severe kidney dysfunction in CHF patients.