Efficiency of Gum Resin Ferula Asafetid in Correction of Disturbances of the Liver in Acute Paracetamol-Induced Hepatitis in Rats

Abstract

Acute toxic hepatitis induced by paracetamol (APIH) in adult white male rats 180-200 g., experimental therapy with gum-resin Ferula asafoetida (GRFA) at doses 50 mg/kg led to a clear elimination of reduced bile secretion, assessed by the intensity of exocrine liver function and the chemical composition of bile, in which bile secretion increased by 101.7%, quantity of bile acids by 46.6%), cholesterol by 54.6% and bilirubin by 56.1%. The doubling of the dose of the medicine (100 mg/kg) did not cause to increase the effect. The positive therapeutic effect of GRFA is also confirmed in the results of the study of "liver function tests" in blood serum. The medicine eliminated the phenomena of hypoproteinemia, hyperbilirubinemia, cytolytic and cholestatic syndromes in rats with acute drug-induced hepatitis. At the same time, GRFA surpasses the reference hepatoprotector - Legalon by its pharmacological activity.