Study of the Anti-Inflammatory Activity of the Polymer Composition of Cotton Cellulose – Gossypol in Male Rats

Abstract

Abstract Gossypol is a typical representative of polyphenolic compounds and it has many pharmacological properties. The aim of this work was to study the effect of the polymer complex gossypol (PCG) - celagripp on the course of aseptic arthritis induced by various phlogogens. The experiments were carried out on sexually matured white male rats with an initial weight of 160-180 g. The anti-exudative effect of the drugs was studied on a model of acute inflammatory edema of the rat paw induced by the injection of the 0.1 ml 2% solution of formalin, 6% solution of dextran and 0.1% solution of histamine into subplantar aponeurosis. Diclofenac sodium at a dose of 10 mg/kg and PCG at doses of 10, 25 and 50 mg/kg were intragastrically administered to the experimental animals 1 hour before the reproduction of the model of inflammation, respectively. It was found that the polymer composition of gossypol from cotton cellulose has a expressed anti-inflammatory activity, which relates to the content of a polyphenolic compound in it. It is believed that its high anti-inflammatory activity in a model of histamine-induced aseptic arthritis is possibly related to antihistamine activity. It was revealed that in terms of its pharmacological activity, the polymer composition of gossypol is inferior to the activity of the reference drug diclofenac sodium in the experiments on aseptic arthritis models.