Association of allelic polymorphism of the proinflammatory cytokine gene VEGFA (rs2010963) with the development and severity of immune microthrombovasculitis

Dilfuza Saburovna Matkarimova , Khamid Yakubovich Karimov , Kodirjon Tukhtabaevich Boboev , Gulnozakhon Atabaevna Matniyazova.

dc.contributor.author	Dilfuza Saburovna Matkarimova , Khamid Yakubovich Karimov , Kodirjon Tukhtabaevich Boboev , Gulnozakhon Atabaevna Matniyazova.
dc.date.accessioned	2022-01-05T09:40:26Z
dc.date.available	2022-01-05T09:40:26Z
dc.date.issued	2021-05-11
dc.identifier.uri	http://repository.tma.uz/xmlui/handle/1/1568
dc.description.abstract	Purpose of the study: To assess the role of the polymorphic variant of the VEGFA (rs2010963) in the development of a severe course of immune microthrombovasculitis (IMTV). The study included 75 patients with immune microthrombovasculitis (IMTV) (main group) aged 16 to 80 years and 73 conditionally healthy individuals (comparison group) without pathology of the hemostasis system, comparable in age and gender with the main group. Detection of polymorphic variants of genes TNF-α (rs 1800629) and VEGFA (rs2010963) was carried out by SNP-PCR. Differences in the frequency of occurrence of the mutant genotype G/G (χ2> 3.8; P< 0.05) of the polymorphic variant of the VEGFA gene (rs2010963) were established depending on the severity of IMTV, which allows clinicians to determine it as a genetic predictor of severe disease	en_US
dc.language.iso	en	en_US
dc.publisher	American journal of medicine and medical sciences	en_US
dc.relation.ispartofseries	DOI:;10.5923/j.ajmms.20211105.16
dc.subject	VEGFA (rs2010963), immune microthrombovasculitis (IMTV), allele, genotype, pathogenesis, severity of the course	en_US
dc.title	Association of allelic polymorphism of the proinflammatory cytokine gene VEGFA (rs2010963) with the development and severity of immune microthrombovasculitis	en_US
dc.type	Article	en_US