Diagnostic Significance of 14-3-3 η (Eta) Protein and MRI of Joints in Early Stage of Rheumatoid Arthritis

Abstract

The aim of our study was to study the sensitivity of 14-3-3 η (Eta) protein in the blood and conducting of MRI (magnetic resonance imaging) of the joints of the hands in the diagnosis of rheumatoid arthritis (RA) in the early stages of disease. The study included 68 patients aged 19 to 74 years (mean age 44.2 ± 3.2 years) with RA onset (meeting the EULAR / ACR criteria, 2010) with a disease duration of up to 1 year (from 6 to 52 weeks.), in the I clinic of TMA for the period 2019 - 2020. All patients underwent a general clinical and biochemical blood test, immunological blood test (rheumatoid factor (RF), anticyclic citrulline peptide (ACCP) and 14-3-3η (Eta) protein in the blood). Also, radiography (RG) of the hands was carried out, as well as MRI of the joints of the hands. Determination of 14-3-3η (Eta) protein and MRI of joints have a sensitivity comparable to that of RF, ACCP, RG and are highly effective methods for diagnosing early RA, which, in combination with other research methods, helps to establish a diagnosis of the disease at an early stage, which contributes to the timely the appointment of an adequate basic treatment.