ЛИПИДНЫЙ СПЕКТР И МАРКЁРЫ СОСУДИСТОГО ВОСПАЛЕНИЯ У БОЛЬНЫХ СО СТАБИЛЬНОЙ СТЕНОКАРДИЕЙ С САХАРНЫМ ДИАБЕТОМ

Abstract

Markers of the vascular inflammatory process were studied in 69 patients aged 60.3±9.8 years with a diagnosis of coronary heart disease in combination with type 2 diabetes. Highly sensitive C-reactive protein and fibrinogen were identified as biochemical markers of inflammation. Comparative analysis of laboratory parameters of the lipid profile at the initial stage revealed a significant excess of the level of total cholesterol, LDL in the 2nd group of patients with coronary heart disease and DM compared with the 1st group. Evaluation of the parameters of the inflammatory reaction registered significantly higher levels of CRP and fibrinogen in the 2nd group of patients, respectively. In group 1, there was a tendency to increase the level of CRP and fibrinogen. Evaluation of correlations between the studied parameters in group 2 revealed the presence of direct correlations between significantly high rates of atherogenic lipids, a qualitative indicator of the presence of DM and an increased level of glycated hemoglobin, which may indicate the involvement of carbohydrate metabolism disorders in the pathogenesis of coronary atherosclerosis.