Toxic Hepatitis of the Female and the Structural and Functional Formation of the Lean Intestine of the Offspring in the Period Breastfeeding

Abstract

Despite ongoing therapeutic and preventive measures, chronic hepatitis of viral etiology still makes up a significant proportion of extra genital pathology among women of childbearing age. On sexually mature female white outbred rats before pregnancy, chronic heliothrine intoxication was created, leading to the development of chronic aggressive hepatitis. The influence of maternal hepatitis on the structural and functional development and enzymatic activity of the jejunum of the lean intestine of the offspring during breastfeeding was researched. Morphological studies have established that a decrease in the average number of villi on a transverse section of the intestine, a decrease in the height of the villi, a decrease in the average number of enterocytes (EC) on a transverse section of the crypt, a decrease in the thickness of the mucous membrane and muscular-serous membranes progressing up to 15 days and a decrease in the height of the EC of the middle third of the crypts to 7 days of development of rat pups. It was also established a decrease in the average number of EC on a longitudinal section of the crypt and villus, and a decrease in the number of mitotically dividing cells up to 21 days of development. That is, structurally revealed a lag in the development of the jejunum in the period of early postnatal ontogenesis, progressing to the transition of rat pups to mixed and definitive nutrition. In functional researches in the offspring of females with chronic toxic hepatitis, a delay in the natural age-dependent induction of the basal level of enteral enzymes: maltase, γ-amylase, sucrose and inhibition of lean intestine lactase during lactation was established. The authors believe that chronic maternal hepatitis leads to lactase deficiency in the offspring, which can lead to widespread diarrhea and other diseases of the gastrointestinal tract in children worldwide.