Effectiveness of vitamin D in the treatment of bone remodeling in ankilozing spondyloarthritis

Abstract

Objective: To study the effectiveness of vitamin D (alphacalcidol) in the treatment of osteoporosis (OP) in patients with ankylosing spondylitis (AS). Results. 52 patients with OP identified AS were divided into 2 groups: group 1 - 24 patients receiving alphacalcidol 0.5-1 mcg "Mineralf", group 2 - 28 patients receiving 1000 mg of calcium. All indications were re-examined before and 6 months after treatment. When patients were treated with alphacalcidol for 6 months, bone and spine pain decreased by 27.2% (Ð <0.001) and muscle strength increased by 16.1% (R <0.05). In the control group, no positive clinical results were observed. Patients responded well to alphacalcidol. Side effects were almost non-existent. Only 1 patient had hypercalcemia at a dose of 1 mcg per day, and another had a headache.