Predictor serum biom or serum biomarkers of cardio arkers of cardiovascular damage in COVID-19

Abstract

Purpose of the study: Retrospective assessment of the peculiarities of changes in the clinical and laboratory parameters of patients with COVID-19 and concomitant cardiovascular pathology. Materials and methods. A retrospective analysis of medical records of 92 patients was. All patients with COVID-19 underwent routine blood tests, including a complete blood count, coagulation profile, lipid spectrum and liver and kidney function, inflammatory biomarkers. Results. According to the results of the study, in the included 92 patients with COVID-19, CVD was found in 32 patients (35.7%). When studying the medical records of patients of the first group with COVID-19 without cardiovascular pathology, the following data of clinical and laboratory parameters were obtained: in the study of a detailed biochemical blood test, an excess of the reference (10-120 μg / l) values of ferritin (192.4 μg / l, p <0.05), C-reactive protein (18.19 mg / l versus the reference 0-5 mg / l, p <0.05), hemostasiogram values: increased fibrinogen (7.25 g / l versus 2.76-4.71 g / l, p <0 , 05), D dimers (437.8 ng / ml versus 0-255 ng / ml, p <0.05). In the second group COVID-19 with cardiovascular pathology (n = 30), the following data of clinical and laboratory parameters were obtained: when studying a detailed biochemical analysis, an excess of ferritin content was revealed (518.36 μg / l versus 192.4 μg / l, the difference is 169.42%, p < 0.05), C-reactive protein (38.67 mg / L versus 18.19 mg / L, the difference is 112.6%, p <0.05), glucose concentration (7.67 mmol / L versus 4.9 -5.1 mmol / L, p <0.05). Conclusions. Thus, it is advisable to involve survivors after COVID-19 in medical rehabilitation programs for faster and better recovery of the functions of various systems (primarily respiratory and cardiovascular), improving the quality of life and reducing the risk of disability.