Specific morphological changes of peripheric immunocompetent members in Sars-Cov-2

Abstract

Specific morphological changes of immune organs in Covid-19 depend on the general reactivity of the organism, age, sex and the degree of development of the pathological process, if the process develops chronically; many sclerotic and atrophic changes develop in immune organs. In this study, SARS-CoV-2 was characterized by the development of specific sclerotic and atrophic changes in the active areas of the spleen and lymph nodes. In particular, a decrease in lymphocytes in the T and V areas of the lymph node and in the lymphoid follicles of the spleen and a quantitative decrease in the number of T lymphocytes around the pulp arteries were studied. These morphological changes, in turn, lead to a decrease in immunocompetent cells, low local detection of T and V lymphocytes, and the development of mixed-type cellular and humoral immunodeficiency.